After all the scare scenarios (and one compelling ABC TV movie last year) about avian influenza, and after the 2003 SARS epidemic, it sounds ironic that the first federally ordered quarantine in the United States would come from a case of tuberculosis in a man ("patient X") with no symptoms.
This TB XDR appears to be a variant of conventional TB that is resistant to most antimycobaterial antibiotics, and it seems to have a 50% mortality rate in those with active symptoms. But apparently this is not mycobacterium avium intercullulae, a brain tuberculosis that affects only severely immunocompromised patients as those with HIV. This can affect people with normal immune systems, but normally TB is quite hard to catch with incidental contact. The chances are that none of the people on the aribuses were infected.
Still, the government is quarantining someone (as a potential "typhoid Mary") with no symptoms. Imagine this with SARS, bird flu, or smallpox (if it ever came back).
Tuberculosis is called the "white plague" in the 1950 World Book Encyclopedia. Consumption, as it was called two generations ago, was dreaded. People went to sanatoriums.
In the 1980s there was scare talk in the gay community of quarantine for PWA's. HIV is transmitted only through direct blood contact, but it is imaginable that an HIV infected population could "amplify" a semi-opportunistic infection like regular TB that could then affect the outside population. But this has never happened in the developed world, despite the scare talk from the religious right.
When I volunteered to be tested for a GP160 HIV vaccine in 1988 at NIH, I had a thorough physical including chest Xray that found a spot. Nurses said that TB is very hard to catch in normal household or social circumstances. NIH did a cat scan, and found it to be a "calcified lymph node," probably from histoplasmosis exposure when I lived in Texas. (Histoplasmosis is another pseudo-opportunistic infection that often causes no symptoms, but just gets walled off in a spot or two in the lungs or liver.)
Hopefully, patient X would gradually overcome the TB with his own immune system even without antibiotics, and that his body would wall the infection off into isolated lymph nodes that will show up on a cat scan. Without symptoms, this may be happening already. It seems unlikely that he is really a "threat."
TB, though, still strikes some fear. School employees must have a negative tuberculin test or Xray, even though TB is really quite hard to transmit most of the time.
It has been reported that the man, himself an attorney, could face civil liabilities if any other airplane passenger became infected with the same strain of TB. (He got past the TSA no fly lists.) He will not face criminal charges. But I've never heard of a case of civil liability for acting as a "carrier" of an infectious disease sometimes spread by casual contact, only for STD's. Such litigation could have downstream consequences with other medical issues.
Thursday, the patient was identified as Robert Speaker, son-in-law of CDC microbiologist Robert C. Cooksey. There seems to be no chance that the infection could have somehow come from CDC itself. It was probably acquired in travel in southeast Asia.
Update: 6/10/2007
Howard Markel, professor of communicable diseases at the University of Michigan, has an op-ed "Typhoid Andy: Return of the White Plague" on page B1 (commentary) of the June 10, 2007 Washington Post. The link is this.
The article takes the position that an asymptomatic carrier of TB can be very dangerous to others, although generally TB is very hard to "catch" (unlike how bird flu could be if it mutated into a contagious form). Mr. Speaker was reported to have a lesion the size of a tennis ball in his lung, but recent sputum tests have been negative, and he may be allowed out of isolation.
Update: July 3, 2007
Media sources reported a new diagnosis for Mr. Speaker, MDR (multiple drug resistant) rather than XDR (extreme drug resistant), which opens up the possibility of much wider drug treatments without surgery. It is unclear whether isolation is as critical with MDR TB.
Update: July 13, 2007
At least eight passengers filed suit in Canadian court against Speaker for exposing them to tuberculosis. One passenger has tested positive for TB, although it is not clear that it is the same strain. It is not clear how enforceable a Canadian judgment would be. But allowing lawsuits based on exposure to an infectious disease through casual contact from someone without symptoms would seem to set a dangerous legal precedent, allowing frivolous litigation. What do we do if this happens with avian influenza? CNN story here.
Update: Dec. 31, 2007
There has been another case involving a native of Nepal. The CDC is recommending screening of other passengers on a particular international flight. The story in USA Today Dec 31, 2007 is by Steve Sternberg, "CDC seeks fliers exposed to drug-resistant TB," here.





